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Molecular Structures Core

The Molecular Structures Core (MSC) enables researchers to determine the structures and dynamics, or motions, of large biomolecules such as proteins and DNA to understand how they interact with each other and with small molecules such as drugs.

Bruker 800 & 600 MHz Avance NEO NMR Spectrometers
The NMR systems are optimized for biomolecular applications. Both are equipped with TCI cryoprobes for unparalleled signal-to-noise, allowing acquisition of protein spectra at as low as 10 μM concentration. The systems are capable of direct detection of 1H, 2H, 13C, 15N, and 19F, and all channels other than 2H have the sensitivity advantage of cryo-cooled electronics.

Bruker X-ray Diffractometer
Our Bruker Venture system is designed for single-crystal X-ray diffractometry. It uses an Excillum liquid gallium X-ray generator producing a 75 μm (FWHM) beam of ≥ 3.5x1011 photons/s/mm2 and a Photon III detector for maximum sensitivity shutterless data collection. An Oxford 800 cryostream is available to maintain crystals at 100 K.

In addition to state-of-the-art equipment used to examine large molecules, experienced staff to help design and conduct experiments, as well as analyze data, provide training, and operate equipment is available.