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Faculty participating in the program hold appointments in either the Department of Chemistry and Biochemistry, or the Department of Pharmacology and Toxicology.

Faculty Research Interests

Craig A. Aspinwall

Cellular Function at the Interface of Analytical Chemistry and Cell Physiology

Michael Brown

NMR spectroscopy; membrane proteins and lipid bilayers; receptors and biological signaling; vision

Eli Chapman
Pharmacology and Toxicology

Protein-guided therapeutic discovery; Chemical biology to study p97 biochemistry and biophysics; Small-molecule based therapeutic discovery and development

Pascale Charest Chemistry/Biochemistry

Signaling mechanisms and directed cell motility

Matthew Cordes

Structural Evolution and Conformational Switching in Proteins

Xinxin Ding
Pharmacology and Toxicology

Drug metabolism/disposition, enzyme function/regulation, drug safety/efficacy, and Genetic/enviromental risks for chemical toxicity
James Galligan
Pharmacology and Toxicology
Studying cell metabolism and chromatin function

Indraneel Ghosh

Signal Transduction Pathways, Anti-Cancer Agents and Protein Based Biosensors

Michael Heien Chemistry/Biochemistry

Measuring neurotransmitters and neuromodulators.  Specifically to figure out how chemicals affext individual neurons and behavior. The goal of his research is to understand the molecular mechanisms behind synapse formation, the role of supporting cells in modulation of neurotransmission, and how these work to regulate behavior

Nancy Horton

Macromolecular structure and function; X-ray crystallography

Victor J. Hruby

Asymmetric Synthesis; Biologically Active Peptides/Mimetics; Conformation-Activity Relationships

Christopher Hulme

Enabling chemistries and platform technologies for the construction of targeted small molecule libraries that span possible applications across multiple target families

John Jewett

Chemical virology - Developing chemical tools to study dengue virus

Nam Lee

Metabolism, Signaling, and Regulation Protein and Membrane Biochemistry
Hongmin Li
Pharmacology and Toxicology

Structural biology, X-ray crystallography, protein-protein interaction, target-based drug discovery, high throughput screening.

Michael Marty

Membrane proteins play a number of critical biochemical roles and make up the majority of drug targets. Despite their importance, membrane proteins remain challenging systems for analysis due to their amphipathic nature and low expression levels. Moreover, the lipid bilayer can play an important but largely unexplored role in regulating membrane protein structure and function. New analytical and biochemical methods are necessary to better understand and design drugs to target membrane proteins.

Katrina M. Miranda

Chemical Biology of Nitrogen Oxides; New Detection Techniques and Donors of Nitrogen Oxides; Drug Development

William R. Montfort

Protein structure, function and dynamics; X-ray crystallography

Jon Njardarson Chemistry/Biochemistry

Organic synthesis, medicinal chemistry and drug development

Aikseng Ooi
Pharmacology and Toxicology

NRF2 signaling, Iron metabolism, Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC), Computational Biology.

Robin L. Polt

Cell-surface Carbohydrates

S. Scott Saavedra

Interfacial Optics, Biofilms, Biosensors

Rick Schnellmann
Pharm/Tox - DDD

Identifying and developing drugs to treat acute kidney injury, diabetic kidney disease, stroke, spinal cord injury and Parkinson’s disease.

Catharine L. Smith
Pharmacology and Toxicology

Epigenetic mechanisms of gene expression, their regulation through signaling pathways and modulation by anti-cancer drugs

Daekyu Sun
Pharmacology and Toxicology

Regulation of gene expression with chemicals

Gregory Thatcher
Pharmacology and Toxicology

Drug Discovery from design through clinical trials. Use of chemical, molecular, and structural biology tools to understand biomolecule targets and design small molecules to engage these targets in cell and animal models.

Thomas Tomasiak Chemistry/Biochemistry

Advanced structural approaches (x-ray crystallography and cryo-EM) and membrane protein stabilization techniques based on lipid nanodiscs to address pharmacological problems involving eukaryotic lipid and drug transporters.

Elisa Tomat

Biological inorganic chemistry of oxidative stress, wound healing, cell proliferation and cancer

Wei Wang
Pharm/Tox - DDD
Organic synthesis, molecular imaging and recognition, chemical biology and medicinal chemistry (drug discovery)

Jun Wang
Pharmacology and Toxicology

Medicinal chemistry and pharmacology of antivirals targeting emerging and re-emerging respiratory viruses including influenza virus, enterovirus D68, and coronaviruses such as SARS-CoV-2; Structure-based drug design targeting ion channels, protein-protein interactions, cysteine proteases and scaffold proteins.

Georg Wondrak
Pharmacology and Toxicology

Molecular pathways of skin photocarcinogenesis that involve cellular photooxidative and carbonyl stress; Developing chemical reagents into potent drugs that target reactive chemical intermediates

Donna Zhang
Pharmacology and Toxicology

The Nrf2/Keap1 signaling pathway that is activated by oxidative stress and chemopreventive compounds; Regulation of gene expression by the ubiquitination and proteasomal degradation pathway