Faculty participating in the program hold appointments in either the Department of Chemistry and Biochemistry, or the Department of Pharmacology and Toxicology.
Craig A. Aspinwall
Cellular Function at the Interface of Analytical Chemistry and Cell Physiology
NMR spectroscopy; membrane proteins and lipid bilayers; receptors and biological signaling; vision
Protein-guided therapeutic discovery; Chemical biology to study p97 biochemistry and biophysics; Small-molecule based therapeutic discovery and development
Pascale Charest Chemistry/Biochemistry
Signaling mechanisms and directed cell motility
Structural Evolution and Conformational Switching in Proteins
Signal Transduction Pathways, Anti-Cancer Agents and Protein Based Biosensors
Michael Heien Chemistry/Biochemistry
Measuring neurotransmitters and neuromodulators. Specifically to figure out how chemicals affext individual neurons and behavior. The goal of his research is to understand the molecular mechanisms behind synapse formation, the role of supporting cells in modulation of neurotransmission, and how these work to regulate behavior.
Macromolecular structure and function; X-ray crystallography
Victor J. Hruby
Asymmetric Synthesis; Biologically Active Peptides/Mimetics; Conformation-Activity Relationships
Enabling chemistries and platform technologies for the construction of targeted small molecule libraries that span possible applications across multiple target families
Laurence H. Hurley
Development of antitumor agents
Chemical virology - Developing chemical tools to study dengue virus
Membrane proteins play a number of critical biochemical roles and make up the majority of drug targets. Despite their importance, membrane proteins remain challenging systems for analysis due to their amphipathic nature and low expression levels. Moreover, the lipid bilayer can play an important but largely unexplored role in regulating membrane protein structure and function. New analytical and biochemical methods are necessary to better understand and design drugs to target membrane proteins.
Katrina M. Miranda
Chemical Biology of Nitrogen Oxides; New Detection Techniques and Donors of Nitrogen Oxides; Drug Development
William R. Montfort
Protein structure, function and dynamics; X-ray crystallography
Jon Njardarson Chemistry/Biochemistry
Organic synthesis, medicinal chemistry and drug development
X-ray crystallography NMR Spectroscopy Cell Signaling Cancer Antibiotic Resistance Protein Phosphatases Protein Kinases Toxin antitoxin systems
NMR Spectroscopy X-ray crystallography Protein function Signaling cascades Cancer Diabetes Protein Phosphatases Protein Kinases
Robin L. Polt
S. Scott Saavedra
Interfacial Optics, Biofilms, Biosensors
Identifying and developing drugs to treat acute kidney injury, diabetic kidney disease, stroke, spinal cord injury and Parkinson’s disease.
Steve Schwartz Chemistry/Biochemistry
Understanding the atomic reaction coordinate of chemical reactions when catalyzed by enzymes and the function of complex protein motor assemblies.
Catharine L. Smith
Epigenetic mechanisms of gene expression, their regulation through signaling pathways and modulation by anti-cancer drugs
Regulation of gene expression with chemicals
Thomas Tomasiak Chemistry/Biochemistry
Advanced structural approaches (x-ray crystallography and cryo-EM) and membrane protein stabilization techniques based on lipid nanodiscs to address pharmacological problems involving eukaryotic lipid and drug transporters.
Elisa Tomat Chemistry/Biochemistry
Biological inorganic chemistry of oxidative stress, wound healing, cell proliferation and cancer
Structure, mechanism, and inhibition of ion channels
Molecular pathways of skin photocarcinogenesis that involve cellular photooxidative and carbonyl stress; Developing chemical reagents into potent drugs that target reactive chemical intermediates
The Nrf2/Keap1 signaling pathway that is activated by oxidative stress and chemopreventive compounds; Regulation of gene expression by the ubiquitination and proteasomal degradation pathway