Nancy C. Horton*^
Life Sciences South, Room 454
Degrees and Appointments:
- B.S. 1986, Southern Illinois University, Carbondale
- Ph.D. 1994, University of Pennsylvania, Philadelphia
- Postdoc 1994-1996, The Upjohn Company
- Postdoc and Fellow 1996-1999, University of California, Santa BarbaraAssistant Researcher I 1999-2001, University of California, Santa Barbara
Specialties: Bioanalytical, Biophysics, Chemical Reaction Dynamics/Kinetics/Interactions​, Metabolism, Signaling, and Regulation, Nucleic Acids and Genomes, Protein and Membrane Biochemistry, Spectroscopy/Molecular Structure, Structural Biology, Theory, Modeling, and Simulation
Research Description
The Horton laboratory is interested in the structures and mechanisms of proteins that act upon DNA and RNA and their consequences to human health. Currently, we are investigating proteins from the human pathogen, Human Parvovirus B19, and as well as enzymes which modulate their activity using filament formation. The methods we employ include structural techniques such as x-ray crystallography, NMR and cryo-electron microscopy, and functional investigations using biochemical and high-throughput methodologies.