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Dimitri Antoniou

Research Associate Professor

Degrees and Appointments

  • Ph.D. (Theoretical Condensed Matter Physics) 1991, Indiana University

Applications of statistical physics to chemical and biological systems:
- Effect of fast motions in enzymatic catalysis
- Rare reactive events in enzymes: transition path sampling
- Algorithms for multivariable data analysis of enzymatic motions

 


R. Harijan, I. Zoi, D. Antoniou, S. Schwartz and V. Schramm: Inverse enzyme isotope  effects in human purine nucleoside phosphorylase with heavy asparagine labels, PNAS 115, 6209 (2018)

I. Zoi, D. Antoniou and S. Schwartz: Electric fields and fast protein dynamics in enzymes, J. Phys. Chem. Lett. 8, 6165-6170 (2017)

I. Zoi, D. Antoniou and S. Schwartz: Incorporating fast protein dynamics into enzyme design: a proposed mutant aromatic amine dehydrogenase, J. Phys. Chem. B 121, 7290-7298 (2017)

R. Harijan, I. Zoi, D. Antoniou, S. Schwartz and V. Schramm: Catalytic-site design for inverse heavy-enzyme isotope effects in human PNP, Proc.  Nat. Acad. Sci. USA 114, 6456-6461 (2017)

I. Zoi, J. Suarez, D. Antoniou, S. Cameron, V. Schramm and S. Schwartz: Modulating enzyme catalysis through mutations designed to alter rapid protein dynamics, J. Am. Chem. Soc. 138, 3403-3409 (2016)

D. Antoniou and S. Schwartz: Phase space bottlenecks In enzymatic reactions, J. Phys. Chem. B  120, 433-439 (2016)

Z. Wang, D. Antoniou, S. Schwartz and V. Schramm: Hydride transfer In DHFR by transition path sampling, kinetic isotope effects, and heavy enzyme studies, Biochemistry 55, 157-166 (2016)

M. Dzierlenga, Antoniou and S. Schwartz: Another look at the mechanisms of hydride transfer enzymes with quantum and classical Transition Path Sampling, J. Phys. Chem. Lett. 6, 1177-1181 (2015)

I. Zoi, M. Motley, D. Antoniou, V. Schramm and S. Schwartz: Enzyme homologues have distinct reaction paths through their transition states, J. Phys. Chem. B 119, 3662-3668 (2015)

M. Dametto, D. Antoniou and S. Schwartz: Barrier crossing In DHFR does not involve a rate-promoting vibration, Mol. Phys. 110, 531-536 (2012)

D. Antoniou, X. Ge, V. Schramm and S. Schwartz: Mass modulation of protein dynamics associated with barrier crossing on PNP, J. Phys. Chem. Lett. 3, 3538-3544 (2012)