Katrina Miranda

Associate Professor

Katrina Miranda

Associate Professor

Degrees and Appointments 

  • B.S. Chemistry, 1989, Northern Arizona University
  • Ph.D. Chemistry, 1996, University of California, Santa Barbara
  • Postdoctoral Fellow, 1996-1998, Department of Cell Biology and Physiology, University of New Mexico School of Medicine
  • Cancer Research Fellow, 1998-2002, National Cancer Institute, NIH

Awards and Honors

  • NSF CAREER Award, 2007
  • Presidential Early Career Award for Scientists and Engineers (PECASE), 2008
  • Achievement Award for Outstanding Mentor of Graduate/Professional Students (GPS), GPS Council, 2010
  • Fellow of the American Association for the Advancement of Science (AAAS), 2013
  • College of Science Distinguished Advising Award, University of Arizona, 2014

Research Specialties: Bioanalytical, Bioinorganic, Chemical Biology, Metabolism, Signaling, and Regulation, Protein and Membrane Biochemistry, Spectroscopy/Molecular Structure, Synthesis/Synthetic Methods Development

Research

Cell survival, development, replication, repair and adaptation depend on the ability to sense and respond to acute and chronic environmental changes. One mechanism by which cells detect, communicate and adjust to changing conditions involves chemical modifications to proteins, DNA and lipids. A subset of these modifications is mediated by small, redox active molecules, including reactive oxygen species (ROS), which are produced by reduction of molecular oxygen, and reactive nitrogen species (RNS), which typically originate from and are more oxidized than nitric oxide (NO). Redox signaling is a major component of intracellular communication, immune response and wound healing but can also contribute to chemical stress and cell death when dysregulated. 

Understanding the chemical and biological basis for the differences in outcome of redox signaling agent production is a challenge that my research program is addressing, with the goal of identifying critical factors and markers of disease development. We also produce nitrogen oxide donors as analytical and pharmacological tools, with a long-term goal of harnessing signaling mechanisms and or modulating key targets for the treatment of cancer, heart failure, pain and alcoholism. Read More.

Faculty Tenure Track Faculty Biochemistry Inorganic Chemistry