ORGINS Seminar: "Development and Mechanistic Studies of Photocatalytic Functionalization of Aryl Halides"


4 to 5 p.m., April 29, 2024


Mubarak Hossain, Ph.D. candidate, Chemistry and Biochemistry, The University of Arizona

Photo of Mubarak Hossain


Aromatic compounds are prevalent in various fields, spanning from cutting-edge pharmaceuticals to polymers and materials science. This underscores the ongoing demand for innovative approaches to disconnecting aromatic rings to push the boundaries of applied research further. Classic methods for arylation reactions rely on transition metal-based cross-coupling reactions where aryl halides are the most commonly used arene source. While effective, these approaches have inherent toxicity concerns, are operationally expensive, thus rendered unsustainable in many regards. Photoredox catalysis has emerged as a robust technique for developing new synthetic methodologies, offering selective activation of organic substrates under mild conditions through the use of open-shell intermediates via single electron transfer pathways. In this context, milder green and red-light mediated photocatalytic aryl halide functionalization and a detailed study on mechanistically less understood pathways are disclosed herein.

Bio Sketch:

I grew up in the heart of the capital city Dhaka in Bangladesh. After receiving my Bachelor of Pharmacy, I pursued my Master of Pharmacy in Pharmaceutical Chemistry at the University of Dhaka. During my Master’s research on natural product chemistry I realized my passion for organic chemistry. Following the completion of my Master’s I decided to move on to pursue my PhD in the discipline of organic synthesis at the University of Arizona. I joined the Gianetti lab in November 2018 and currently finishing up my doctoral research with Dr. Thomas Gianetti. Here, a major part of my research is focused on photocatalysis; in simple term exploiting energy from light to accomplish challenging organic transformations.

Hosted by: Dr. Thomas Gianetti