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Structural Biology

We are interested in understanding how DNA binding proteins perform their various functions including sequence recognition, DNA cleavage, methylation, unwinding, and related functions. DNA binding proteins are important in biology in the manipulation of DNA and in transcription of genes. DNA repair is important in maintaining genetic integrity and preventing diseases such as cancer. We are also interested in the evolution of function in DNA binding proteins and in the evolution of DNA repair pathways in eukaryotes.



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